Sienna to Noto trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Noto every about 3 hours on average. If travelling with Trenitalia, you need to know the Sienna to Noto train schedule: the first train leaves at 17:43, while the last ride is at 21:26. A Sienna to Noto train cost about 82.85 €. But how long is the train ride from Sienna to Noto? Your journey takes about 18 hours on average.