Sienna to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Sienna to Palermo train schedule: the first train leaves at 17:43, while the last ride is at 21:26. A Sienna to Palermo train cost about 95.55 €. But how long is the train ride from Sienna to Palermo? Your journey takes about 20 hours on average.