Sienna to Quattromiglia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Castiglione Cosentino every about 2 hours on average. If travelling with Trenitalia, you need to know the Sienna to Quattromiglia train schedule: the first train leaves at 06:36, while the last ride is at 21:26. A Sienna to Quattromiglia train cost about 90.9 €. But how long is the train ride from Sienna to Quattromiglia? Your journey takes about 10 hours on average.