Sienna to San Cataldo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at S. Cataldo every about 12 hours on average. If travelling with Trenitalia, you need to know the Sienna to San Cataldo train schedule: the first train leaves at 18:43, while the last ride is at 18:43. A Sienna to San Cataldo train cost about 153.5 €. But how long is the train ride from Sienna to San Cataldo? Your journey takes about 20 hours on average.