Sienna to Trapani trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Trapani every about 6 hours on average. If travelling with Trenitalia, you need to know the Sienna to Trapani train schedule: the first train leaves at 18:02, while the last ride is at 18:43. A Sienna to Trapani train cost about 140.4 €. But how long is the train ride from Sienna to Trapani? Your journey takes about 20 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Trapani and find low cost tickets starting from 97 €!