Sienna to Trapani trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Trapani every about 6 hours on average. If travelling with Trenitalia, you need to know the Sienna to Trapani train schedule: the first train leaves at 18:02, while the last ride is at 18:43. A Sienna to Trapani train cost about 140.4 €. But how long is the train ride from Sienna to Trapani? Your journey takes about 20 hours on average.