Sienna to Trieste trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Trieste Centrale every 60 minutes on average. If travelling with Trenitalia, you need to know the Sienna to Trieste train schedule: the first train leaves at 06:36, while the last ride is at 21:26. A Sienna to Trieste train cost about 48.7 €. But how long is the train ride from Sienna to Trieste? Your journey takes about 8 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Trieste and find low cost tickets starting from 52 €!