Sienna to Varese trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Varese every about 2 hours on average. If travelling with Trenitalia, you need to know the Sienna to Varese train schedule: the first train leaves at 06:36, while the last ride is at 18:18. A Sienna to Varese train cost about 72.5 €. But how long is the train ride from Sienna to Varese? Your journey takes about 6 hours on average.