Sienna to Venice trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Venezia S. Lucia every 60 minutes on average. If travelling with Trenitalia, you need to know the Sienna to Venice train schedule: the first train leaves at 05:00, while the last ride is at 20:24. A Sienna to Venice train cost about 29.00 €. But how long is the train ride from Sienna to Venice? Your journey takes about 5 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Venice and find low cost tickets starting from 38 €! When booking your train ticket a few weeks in advance though, you can find low cost trains from Sienna to Venice with fares starting from 29.00€, saving up to 20%.