Sienna to Vicenza trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Vicenza every 30 minutes on average. If travelling with Trenitalia, you need to know the Sienna to Vicenza train schedule: the first train leaves at 07:02, while the last ride is at 21:26. A Sienna to Vicenza train cost about 37.75 €. But how long is the train ride from Sienna to Vicenza? Your journey takes about 5 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Vicenza and find low cost tickets starting from 26 €!