Spoleto to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Spoleto and arrive at Castelvetrano every about 6 hours on average. If travelling with Trenitalia, you need to know the Spoleto to Castelvetrano train schedule: the first train leaves at 05:15, while the last ride is at 19:02. A Spoleto to Castelvetrano train cost about 93.65 €. But how long is the train ride from Spoleto to Castelvetrano? Your journey takes about 17 hours on average.