Spoleto to Marsala trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Spoleto and arrive at Mozia-Birgi every about 12 hours on average. If travelling with Trenitalia, you need to know the Spoleto to Marsala train schedule: the first train leaves at 19:00, while the last ride is at 19:00. A Spoleto to Marsala train cost about 85.45 €. But how long is the train ride from Spoleto to Marsala? Your journey takes about 19 hours on average.