Spoleto to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Spoleto and arrive at Mazara del Vallo every about 12 hours on average. If travelling with Trenitalia, you need to know the Spoleto to Mazara del Vallo train schedule: the first train leaves at 19:02, while the last ride is at 19:02. A Spoleto to Mazara del Vallo train cost about 85.45 €. But how long is the train ride from Spoleto to Mazara del Vallo? Your journey takes about 22 hours on average.