Spoleto to Messina trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Spoleto to Messina. Trains leave from Spoleto and arrive at Messina Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Spoleto to Messina train schedule: the first train leaves at 19:02, while the last ride is at 19:02. A Spoleto to Messina train cost about 92.1 €. But how long is the train ride from Spoleto to Messina? Your journey takes about 11 hours on average.