Spoleto to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Spoleto to Niscemi. Trains leave from Spoleto and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Spoleto to Niscemi train schedule: the first train leaves at 19:02, while the last ride is at 19:02. A Spoleto to Niscemi train cost about 117.05 €. But how long is the train ride from Spoleto to Niscemi? Your journey takes about 22 hours on average.