Spoleto to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Spoleto and arrive at Palermo Notarbartolo every about 12 hours on average. If travelling with Trenitalia, you need to know the Spoleto to Palermo train schedule: the first train leaves at 19:00, while the last ride is at 19:00. A Spoleto to Palermo train cost about 107.8 €. But how long is the train ride from Spoleto to Palermo? Your journey takes about 15 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Spoleto to Palermo and find low cost tickets starting from 34 €!