Spoleto to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Spoleto and arrive at Siracusa every about 4 hours on average. If travelling with Trenitalia, you need to know the Spoleto to Syracuse train schedule: the first train leaves at 08:09, while the last ride is at 19:02. A Spoleto to Syracuse train cost about 83.0 €. But how long is the train ride from Spoleto to Syracuse? Your journey takes about 15 hours on average.