Spoleto to Venice trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Spoleto and arrive at Venezia S. Lucia every about 1 hour on average. If travelling with Trenitalia, you need to know the Spoleto to Venice train schedule: the first train leaves at 05:55, while the last ride is at 22:26. A Spoleto to Venice train cost about 49.75 €. But how long is the train ride from Spoleto to Venice? Your journey takes about 7 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Spoleto to Venice and find low cost tickets starting from 43 €!