Syracuse to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siracusa and arrive at Alessandria every about 2 hours on average. If travelling with Trenitalia, you need to know the Syracuse to Alessandria train schedule: the first train leaves at 13:40, while the last ride is at 21:45. A Syracuse to Alessandria train cost about 113.45 €. But how long is the train ride from Syracuse to Alessandria? Your journey takes about 21 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Syracuse to Alessandria and find low cost tickets starting from 47 €!