Syracuse to Isernia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siracusa and arrive at Isernia every about 3 hours on average. If travelling with Trenitalia, you need to know the Syracuse to Isernia train schedule: the first train leaves at 19:10, while the last ride is at 21:45. A Syracuse to Isernia train cost about 49.0 €. But how long is the train ride from Syracuse to Isernia? Your journey takes about 15 hours on average.