Termoli to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Termoli and arrive at Messina Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Termoli to Messina train schedule: the first train leaves at 06:28, while the last ride is at 18:28. A Termoli to Messina train cost about 81.0 €. But how long is the train ride from Termoli to Messina? Your journey takes about 12 hours on average.