Trieste to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Trieste Centrale and arrive at Palermo Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Trieste to Palermo train schedule: the first train leaves at 05:15, while the last ride is at 20:40. A Trieste to Palermo train cost about 153.40 €. But how long is the train ride from Trieste to Palermo? Your journey takes about 19 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Trieste to Palermo and find low cost tickets starting from 64 €!