Venice to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Venezia S. Lucia and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Venice to Syracuse train schedule: the first train leaves at 00:08, while the last ride is at 16:50. A Venice to Syracuse train cost about 78.0 €. But how long is the train ride from Venice to Syracuse? Your journey takes about 21 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Venice to Syracuse and find low cost tickets starting from 89 €!