Vicenza to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Vicenza to Niscemi. If travelling with Trenitalia, you need to know the Vicenza to Niscemi train schedule: the first train leaves at 18:26, while the last ride is at 23:02. A Vicenza to Niscemi train cost about 143.75 €. But how long is the train ride from Vicenza to Niscemi? Your journey takes about 23 hours on average.