Vicenza to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Vicenza and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Vicenza to Syracuse train schedule: the first train leaves at 07:05, while the last ride is at 23:02. A Vicenza to Syracuse train cost about 123.05 €. But how long is the train ride from Vicenza to Syracuse? Your journey takes about 17 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Vicenza to Syracuse and find low cost tickets starting from 124 €!