Alpignano to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Alpignano and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Alpignano to Messina train schedule: the first train leaves at 06:25, while the last ride is at 20:55. A Alpignano to Messina train cost about 111.2 €. But how long is the train ride from Alpignano to Messina? Your journey takes about 15 hours on average.