Anzio to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Villa Claudia and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Anzio to Messina train schedule: the first train leaves at 06:06, while the last ride is at 20:23. A Anzio to Messina train cost about 57.9 €. But how long is the train ride from Anzio to Messina? Your journey takes about 10 hours on average.