Avezzano to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Avezzano and arrive at Messina Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Avezzano to Messina train schedule: the first train leaves at 06:56, while the last ride is at 19:10. A Avezzano to Messina train cost about 45.3 €. But how long is the train ride from Avezzano to Messina? Your journey takes about 12 hours on average.