Brindisi to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Castelvetrano every about 3 hours on average. If travelling with Trenitalia, you need to know the Brindisi to Castelvetrano train schedule: the first train leaves at 07:49, while the last ride is at 20:38. A Brindisi to Castelvetrano train cost about 79.05 €. But how long is the train ride from Brindisi to Castelvetrano? Your journey takes about 2 hours on average.