Brindisi to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Niscemi every about 6 hours on average. If travelling with Trenitalia, you need to know the Brindisi to Niscemi train schedule: the first train leaves at 20:38, while the last ride is at 20:38. A Brindisi to Niscemi train cost about 67.05 €. But how long is the train ride from Brindisi to Niscemi? Your journey takes about 1 hour on average.