Comiso to Spoleto trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Comiso and arrive at Spoleto every about 2 hours on average. If travelling with Trenitalia, you need to know the Comiso to Spoleto train schedule: the first train leaves at 07:10, while the last ride is at 18:22. A Comiso to Spoleto train cost about 74.5 €. But how long is the train ride from Comiso to Spoleto? Your journey takes about 17 hours on average.