Desio to Perugia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desio and arrive at Perugia every 60 minutes on average. If travelling with Trenitalia, you need to know the Desio to Perugia train schedule: the first train leaves at 06:39, while the last ride is at 21:39. A Desio to Perugia train cost about 45.75 €. But how long is the train ride from Desio to Perugia? Your journey takes about 6 hours on average.