Empoli to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Alessandria every 60 minutes on average. If travelling with Trenitalia, you need to know the Empoli to Alessandria train schedule: the first train leaves at 01:15, while the last ride is at 17:58. A Empoli to Alessandria train cost about 23.9 €. But how long is the train ride from Empoli to Alessandria? Your journey takes about 5 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Empoli to Alessandria and find low cost tickets starting from 23 €!