Isernia to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Mazara del Vallo every about 12 hours on average. If travelling with Trenitalia, you need to know the Isernia to Mazara del Vallo train schedule: the first train leaves at 18:58, while the last ride is at 18:58. A Isernia to Mazara del Vallo train cost about 71.95 €. But how long is the train ride from Isernia to Mazara del Vallo? Your journey takes about 23 hours on average.