Madrid to Villarrubia de Santiago trains might be a good value for money solution: travelling in Spain by train is often rather cheap and faster than taking a bus indeed Trains leave from Madrid-Atocha Cercanias and arrive at Villarrubia De Santiago every about 12 hours on average. If travelling with Renfe, you need to know the Madrid to Villarrubia de Santiago train schedule: the first train leaves at 06:20, while the last ride is at 06:20. A Madrid to Villarrubia de Santiago train cost about 7.26 €. But how long is the train ride from Madrid to Villarrubia de Santiago? Your journey takes about 1 hour on average. Renfe offers 1 direct trains between these two cities.