Manfredonia to Brescia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Brescia every about 6 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Brescia train schedule: the first train leaves at 05:53, while the last ride is at 05:53. A Manfredonia to Brescia train cost about 83.75 €. But how long is the train ride from Manfredonia to Brescia? Your journey takes about 10 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Manfredonia to Brescia and find low cost tickets starting from 97 €!