Manfredonia to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Messina Centrale every about 12 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Messina train schedule: the first train leaves at 05:53, while the last ride is at 05:53. A Manfredonia to Messina train cost about 57.6 €. But how long is the train ride from Manfredonia to Messina? Your journey takes about 14 hours on average.