Manfredonia to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Niscemi every about 6 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Niscemi train schedule: the first train leaves at 17:40, while the last ride is at 20:40. A Manfredonia to Niscemi train cost about 71.65 €. But how long is the train ride from Manfredonia to Niscemi? Your journey takes about 12 hours on average.