Mesagne to Avola trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Avola every about 6 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Avola train schedule: the first train leaves at 08:00, while the last ride is at 08:00. A Mesagne to Avola train cost about 72.0 €. But how long is the train ride from Mesagne to Avola? Your journey takes about 22 hours on average.