Mesagne to Monopoli trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Monopoli every about 12 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Monopoli train schedule: the first train leaves at 13:10, while the last ride is at 13:10. A Mesagne to Monopoli train cost about 6.3 €. But how long is the train ride from Mesagne to Monopoli? Your journey takes about 2 hours on average.