Messina to Anzio trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Villa Claudia every about 2 hours on average. If travelling with Trenitalia, you need to know the Messina to Anzio train schedule: the first train leaves at 00:35, while the last ride is at 22:10. A Messina to Anzio train cost about 52.6 €. But how long is the train ride from Messina to Anzio? Your journey takes about 11 hours on average.