Messina to Desenzano del Garda trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Desenzano del Garda-Sirmione every about 1 hour on average. If travelling with Trenitalia, you need to know the Messina to Desenzano del Garda train schedule: the first train leaves at 16:40, while the last ride is at 22:10. A Messina to Desenzano del Garda train cost about 102.15 €. But how long is the train ride from Messina to Desenzano del Garda? Your journey takes about 18 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Messina to Desenzano del Garda and find low cost tickets starting from 99 €!