Messina to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Palermo Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Messina to Palermo train schedule: the first train leaves at 06:45, while the last ride is at 19:10. A Messina to Palermo train cost about 11.8 €. But how long is the train ride from Messina to Palermo? Your journey takes about 3 hours on average. Trenitalia offers 6 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Messina to Palermo and find low cost tickets starting from 12 €!