Messina to Varese trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Varese every about 3 hours on average. If travelling with Trenitalia, you need to know the Messina to Varese train schedule: the first train leaves at 16:40, while the last ride is at 22:10. A Messina to Varese train cost about 107.5 €. But how long is the train ride from Messina to Varese? Your journey takes about 17 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Messina to Varese and find low cost tickets starting from 43 €!