Milan to Mestre trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Centrale and arrive at Venezia Mestre every 30 minutes on average. If travelling with Trenitalia, you need to know the Milan to Mestre train schedule: the first train leaves at 06:35, while the last ride is at 20:35. A Milan to Mestre train cost about 14.90 €. But how long is the train ride from Milan to Mestre? Your journey takes about 2 hours on average. Trenitalia offers 21 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Milan to Mestre and find low cost tickets starting from 19 €! When booking your train ticket a few weeks in advance though, you can find low cost trains from Milan to Mestre with fares starting from 14.90€, saving up to 24%.