Monopoli to Frosinone trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Monopoli and arrive at Frosinone every about 4 hours on average. If travelling with Trenitalia, you need to know the Monopoli to Frosinone train schedule: the first train leaves at 06:23, while the last ride is at 14:54. A Monopoli to Frosinone train cost about 45.1 €. But how long is the train ride from Monopoli to Frosinone? Your journey takes about 7 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Monopoli to Frosinone and find low cost tickets starting from 16 €!