Naples to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Napoli Centrale and arrive at Palermo Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Naples to Palermo train schedule: the first train leaves at 23:53, while the last ride is at 23:53. A Naples to Palermo train cost about 86.2 €. But how long is the train ride from Naples to Palermo? Your journey takes about 10 hours on average. Trenitalia offers 1 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Naples to Palermo and find low cost tickets starting from 24 €!