Osimo to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Osimo-Castelfidardo and arrive at Siracusa every about 4 hours on average. If travelling with Trenitalia, you need to know the Osimo to Syracuse train schedule: the first train leaves at 13:51, while the last ride is at 19:14. A Osimo to Syracuse train cost about 128.6 €. But how long is the train ride from Osimo to Syracuse? Your journey takes about 21 hours on average.