Palagiano to Mesagne trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Palagiano-Mottola and arrive at Mesagne every about 12 hours on average. If travelling with Trenitalia, you need to know the Palagiano to Mesagne train schedule: the first train leaves at 06:48, while the last ride is at 06:48. A Palagiano to Mesagne train cost about 11.2 €. But how long is the train ride from Palagiano to Mesagne? Your journey takes about 3 hours on average.