Palermo to Rome trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Palermo Notarbartolo and arrive at Roma Termini every about 2 hours on average. If travelling with Trenitalia, you need to know the Palermo to Rome train schedule: the first train leaves at 09:10, while the last ride is at 20:44. A Palermo to Rome train cost about 79.0 €. But how long is the train ride from Palermo to Rome? Your journey takes about 13 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Palermo to Rome and find low cost tickets starting from 82 €!