Sesto San Giovanni to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sesto S. Giovanni and arrive at Siracusa every about 1 hour on average. If travelling with Trenitalia, you need to know the Sesto San Giovanni to Syracuse train schedule: the first train leaves at 06:29, while the last ride is at 19:27. A Sesto San Giovanni to Syracuse train cost about 107.1 €. But how long is the train ride from Sesto San Giovanni to Syracuse? Your journey takes about 17 hours on average.